A red-emitting ratiometric fluorescent probe based on a benzophosphole P-oxide scaffold for the detection of intracellular sodium ions

Papers published
Masayasu Taki, Hiroaki Ogasawara, Hiroshi Osaki, Aiko Fukazawa, Yoshikatsu Sato, Kimi Ogasawara, Tetsuya Higashiyama, and Shigehiro Yamaguchi, Chemical Communications. 2015, 51, 11880-11883. DOI: 110.1039/c5cc03547c
  • We disclose the development of a ratiometric fluorescent probe based on a benzophosphole P-oxide and its application for the detection of intracellular Na+ ions. Excitation by visible light induced red emission from this probe in water, which was subjected to a hypsochromic shift upon complexation with Na+. Based on this change, a ratiometric analysis enabled us to visualise changes in the Na+ concentration in living mammalian cells.

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