A covalent G-site inhibitor for glutathione S-transferase Pi (GSTP1-1)

Papers published
Yuko Shishido, Fumiaki Tomoike, Yasuaki Kimura, Keiko Kuwata, Takato Yano, Kenji Fukui, Haruka Fujikawa, Yoshitaka Sekido, Yuko Murakami-Tonami, Tomoshi Kameda, Satoshi Shuto, and Hiroshi Abe*, Chemical Communications, 53, 11138-11141 (2017), DOI: 10.1039/C7CC05829B
  • We herein report the first covalent G-site-binding inhibitor for GST, GS-ESF (1), which irreversibly inhibited the GSTP1-1 function. LC-MS/MS and X-ray structure analyses of the covalently linked GST-inhibitor complex suggested that 1 reacted with Tyr108 of GSTP1-1. The mechanism of covalent bond formation was discussed based on MD simulation results.

Bookmark this on Hatena Bookmark
Hatena Bookmark - A covalent G-site inhibitor for glutathione S-transferase Pi (GSTP1-1)
Share on Facebook
Post to Google Buzz
Bookmark this on Yahoo Bookmark
Bookmark this on Livedoor Clip
Share on FriendFeed
[`tweetmeme` not found]
[`grow` not found]