Selective N-Alkylation of Amines with Alcohols by Using Non-Metal-Based Acid–Base Cooperative Catalysis

Papers published
Ya Du, Shunsuke Oishi, and Susumu Saito, Chem. Eur. J., 2011, 17,12262–12267. 10.1002/chem.201102446
  • A straightforward method for the selective N-mono- and dialkylation of amines with alcohols by means of non-metal-based catalysis promoted by TAPC is reported (see scheme). Selectivity of the N-mono- and dialkylation, substrate scope and functional-group tolerance are highlighted with respect to each amine (1° and 2°; aromatic and aliphatic) and alcohol (1°, 2° and 3°; benzylic and aliphatic) component.

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