Bioorganic Chemistry Laboratory

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Thinking theoretically to design new molecules is the best part of chemistry. Of course, things do not always go as originally planned, but that can actually result in the discovery of interesting phenomena. Getting to the root cause of why something happened can lead to the discovery of new fundamental principles. I believe the fun of creating new things lies in this type of research process. Come and join us and you’ll see!


Laboratory
Bioorganic chemistry Laboratory
Room
Science & Agricultural Building / 5F
Tel
+81-52-789-2490
Site
http://biochemistry.chem.nagoya-u.ac.jp/

Current Articles

1) N. Abe, K. Matsumoto, M. Nishihara, Y. Nakano, A. Shibata, H. Maruyama, S. Shuto, A. Matsuda, M. Yoshida, Y. Ito, H. Abe “Rolling Circle Translation of Circular RNA in Living Human Cells” Scientific Reports, 5, 16435 (2015).


2) K. Onizuka, F. Nagatsugi, Y. Ito, H. Abe “Automatic Pseudorotaxane Formation Targeting on Nucleic Acids Using a Pair of Reactive Oligodeoxynucleotides” J. Am. Chem. Soc., 136, 7201–7204 (2014).


3) A. Shibata, T. Uzawa, Y. Nakashima, M. Ito, Y. Nakano, S. Shuto, Y. Ito, H. Abe “Very rapid DNA templated reaction for efficient signal amplification and its steady-state kinetic analysis of the turnover cycle” J. Am. Chem. Soc., 135, 14172−14178 (2013).


4) N. Abe, M. Hiroshima, H. Maruyama, Y. Nakashima, Y. Nakano, A. Matsuda, Y. Sako, Y. Ito, H. Abe “Rolling circle amplification in a prokaryotic translation system using small circular RNA” Angew. Chem. Int. Ed., 52, 7004-7008 (2013)


5) J. Zhang, A. Shibata, M. Ito, S. Shuto, Y. Ito, B. Mannervik, H. Abe, R. Morgenstern “Synthesis and characterization of a series of highly fluorogenic substrates for glutathione transferases, a general strategy” J. Am. Chem. Soc., 133, 14109-14119, (2011).



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